Overview of Meropenem + Sulbactam Injection:
MERONIS-S Injection contains Meropenem 1g and Sulbactam 0.5g. Meropenem has excellent penetration in abdominal tissues, bile, blister fluid, inflammatory exudate, cerebrospinal fluid (in the presence of inflammation), gynecologic tissues, respiratory tract tissues, and urinary tract tissues. Sulbactam is given in combination with β-lactam antibiotics to inhibit β-lactamase, an enzyme produced by bacteria that destroys the antibiotics.
Meropenem is a broad-spectrum carbapenem antibiotic. Sulbactam is a β-lactamase inhibitor
MERONIS-S Injection can be used in the treatment of the following conditions:
- Bacterial meningitis in children (US FDA)
- Complicated skin and skin-structure infections in adults and children (US FDA)
- Serious intra-abdominal infections in adults and children. (US FDA)
- Bone, and joint infections
- Serious gastrointestinal infections
- Febrile neutropenia
- Nosocomial pneumonia
- Cystic fibrosis-associated respiratory infections
- Serious urinary tract infections.
1-2g MERONIS-S Injection every 8 hours depending on the severity and type of infection, usually given by intravenous infusion over approximately 15 to 30 minutes, or as directed by Physician.
Meropenem causes the inhibition of cell wall synthesis. Meropenem readily penetrates the cell wall of most Gram-positive and Gram-negative bacteria to reach penicillin-binding- protein (PBP) targets. It has strongest affinities towards PBPs 2, 3 and 4 of Escherichia coli and Pseudomonas aeruginosa; and PBPs 1, 2 and 4 of Staphylococcus aureus. Sulbactam is an irreversible inhibitor of β-lactamase; it binds to the enzyme and does not allow it to degrade the antibiotic.