(Ofloxacin 200 mg + Ornidazole 500 mg Tablets)
OFNIS-OZ Tablets contains Ofloxacin and Ornidazole. Notably Ofloxacin has 100 times higher affinity for bacterial DNA gyrase. Ofloxacin tis a broad-spectrum antibiotic active against both Gram-positive and Gram-negative bacteria.
Ornidazole cures protozoan infections. Ornidazole is active against protozoa and anaerobic bacteria and is used in the management of susceptible protozoal and anaerobic bacterial infections. Ornidazole has longer T ½ (12-14 hours) as compared to that of metronidazole (6-8 hours).
Ofloxacin is a second generation fluoroquinolone antibiotic. Ornidazole belongs to the class of nitroimidazole.
OFNIS-OZ Tablets can be used in the treatment of the following conditions:
- Mixed diarrhea
- Postoperative infections
- Upper and Lower respiratory tract infections
- Peritonsillar abscess
- Biliary infections
- Wound infections
- Infections in cancer patients
- Gynecological infections
- Dental infections
- Diabetic foot infections.
1-2 OFNIS-OZ Tablets every 12 hours or as directed by Physician.
Ofloxacin acts on DNA gyrase and toposiomerase IV. Topoisomerase, prevents the excessive supercoiling of DNA during replication or transcription. By inhibiting their function, the drug thereby inhibits normal cell division.
Ornidazole is a 5-nitroimidazole derivative active against protozoa and anaerobic bacteria. It is converted to reduction products that interact with DNA to cause destruction of helical DNA structure and strand leading to a protein synthesis inhibition and cell death in susceptible organisms.