Overview of Cefixime Trihydrate + Ornidazole Tablets:

CEFEXY-OZ Tablets contains Cefixime and Ornidazole. It is highly stable in the presence of beta-lactamase enzymes. The antibacterial effect of Cefixime results from inhibition of mucopeptide synthesis in the bacterial cell wall. Cefixime binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis. Ofloxacin contains an imidazole ring which bears a nitro group. It is an anti-amoebic agent. Ornidazole has a broad spectrum -cidal activity against Protozoa and some anaerobic bacteria.

Cefixime is an antibiotic, third-generation cephalosporin. Ornidazole belongs to the class of nitroimidazoles.

CEFEXY-OZ Tablets are used in the treatment of the following conditions:

  • Diarrhea and dysentery
  • Abdominal infections
  • Dental infections
  • Post-surgical infections
  • Infections of female reproductive tract

1-2 CEFEXY-OZ Tablets once daily or in two divided doses.

Cefixime binds to specific penicillin-binding proteins (PBPs) located inside the bacterial cell wall, causing the inhibition of the third and last stage of bacterial cell wall synthesis. Cell lysis is then mediated by bacterial cell wall autolytic enzymes such as autolysins; it is possible that cefixime interferes with an autolysin inhibitor. Ornidazole has selective toxicity to anaerobic microbes, the mechanism steps involves: Drug enters the cell by diffusion; nitro group of drug is reduced by redox proteins present only in anaerobic organisms to reactive nitro radical which exerts cytotoxic action by damaging DNA and other critical biomolecules; DNA helix destabilization and strand breakage has been observed.