Aceclofenac inhibits cyclooxygenase (COX) activity and to suppress the PGE2 production by inflammatory cells, by inhibiting IL-Beta & TNF in the inflammatory cells (Intracellular Action). Rabeprazole suppress gastric acid secretion by inhibiting gastric H+K+ATPase at the secretory surface, of the gastric parietal cells. Rabeprazole act by blocking the H+P+ ATPase enzyme of the gastric parietal cells, thus inhibit last stage of gastric acid secretion.