Overview of Calcitriol + Calcium Citrate + Magnesium Oxide + Zinc Oxide Softgels:

CALTIN-CZ Softgels contains Calcitriol, Calcium Citrate, Magnesium Oxide and Zinc Oxide. Calcitriol is a form of vitamin D. Calcitriol administration enhances calcium absorption, reduces serum alkaline phosphatase levels, and may reduce elevated parathyroid hormone levels and the histological manifestations of osteitis fibrosa cystica (a skeletal disorder caused by hyperparathyroidism) and defective mineralization.

Calcium is an important mineral for the formation of normal bone tissue. Vitamin-D deficiency can occur at any time of life and may be treated with vitamin D.

In response to hypocalcemia (low blood calcium levels) parathyroid glands secret excessive parathyroid hormone. This disorder is called secondary hyperparathyroidism and is especially seen in patients with chronic kidney failure.

Hypoparathyroidism leads to diminished concentration of parathyroid hormone in the blood, which causes deficiencies of calcium and phosphorus compounds in the blood and results in muscular spasms.

Familial hypophosphatemia is a rare inherited disorder characterized by impaired transport of phosphate and often altered vitamin-D metabolism in the kidneys. It can lead to osteomalacia, which can be considered a softening of bones. Calcium deficiency may also be a contributing factor in the development of nutritional rickets.

CALTIN-CZ Softgel are nutritional supplements. Calcitriol is a form of Vitamin D. Calcium, Magnesium and Zinc are the important minerals required for the health of bones and other body functions.
Secondary hyperparathyroidism in renal failure. Adult: 0.25mcg daily or every other day. May increase by 0.25mcg daily at intervals of 4-8 weeks. Child: 0.25-2mcg daily with haemodialysis.
Hypoparathyroidism/pseudohypoparathyroidism Adult: 0.5-2mcg once daily. Child (1-5 years): 0.25-0.75mcg once daily; >6 years: 0.5-2mcg once daily.
Vitamin D-resistant rickets (familial hypophosphataemia) Adult: 0.015-0.02mcg/kg once daily. Maintenance: 0.03-0.06mcg/kg once daily. Max: 2mcg once daily. Child: 0.015-0.02mcg/kg once daily. Maintenance: 0.03-0.06mcg/kg once daily. Max: 2mcg once daily.

CALTIN CZ Softgels can be used in the treatment of following conditions:

  • Secondary hyperparathyroidism in renal failure.
  • Management of hypocalcemia and the resultant metabolic bone disease in patients undergoing chronic renal dialysis.
  • Hypoparathyroidism/pseudohypoparathyroidism
  • Vitamin D-resistant rickets (Familial Hypophosphataemia)

Parathyroid hormone (PTH) allows body to pull calcium from bones and tells body to start making more activated vitamin D to absorb more calcium in the gut. This helps body keep a narrow and healthy range of calcium in the blood. When calcium is just right in your blood, PTH will lower and stop pulling calcium from bones. In Hypoparathyroidism, PTH is too low that leads to low calcium regulation in the blood that may cause hypocalcemia.

In primary hyperparathyroidism, the parathyroid keeps producing PTH, leading to chronically high PTH levels, high blood calcium (hypercalcemia), and if not treated, bone diseases like osteoporosis and osteomalacia.

Calcitriol increases the calcium level in the blood by increasing the uptake of calcium from the gastric system into the blood, and possibly increasing the release of calcium into the blood from bone. Supplementation with Calcium and Vitamin D might be helpful in such deficiencies and it needs to be closely monitored.

Related Products