Nismentin

(Amoxicillin + Clavulanate Potassium 625 mg Tablets)


Overview:

NISMENTIN Tablets, Injections and Dry Syrup contains Amoxycillinand Clavulanic acid. Co-amoxiclav results in increased spectrum of action and restored efficacy against amoxicillin-resistant bacteria that produce β-lactamase. It is the mainstay of treatment for ear infections and acute exacerbations of chronic bronchitis (AECB).

Amoxicillin belongs to the class of penicillins, and Clavulanic Acid is a beta-lactamase inhibitor.

Antibacterial

NISMENTIN Tablets, Injections and Dry Syrup can be used in the treatment of the following conditions:

  • Acute Exacerbations of Chronic Bronchitis (AECB)
  • Acute bacterial sinusitis
  • Acute otitis media
  • Community acquired pneumonia
  • Cystitis and Pyelonephritis
  • Skin and soft tissue infections in particular cellulitis, animal bites, severe dental abscess with spreading cellulitis
  • Bone and joint infections, in particular osteomyelitis
Oral: Adults and children ≥ 40 kg: One NISMENTIN Tablet every 12 hrs for 10-14 days.
Parenteral: One NISMENTIN Injection thrice daily. In more serious infections, increase frequency to 6 hourly intervals.

Children (3 months to 12yrs)-
30 mg/kg/day of NISMENTIN Dry Syrup. In more serious infections, increase frequency to 6 hourly, or as directed by Physician.

Amoxicillin binds to penicillin-binding protein 1A (PBP-1A) located inside the bacterial cell well. Penicillins acylate the penicillin-sensitive transpeptidase C-terminal domain by opening the lactam ring. This inactivation of the enzyme prevents the formation of a cross-link of two linear peptidoglycan strands, inhibiting the third and last stage of bacterial cell wall synthesis.
Clavulanic Acid binds and irreversibly inhibits the beta-lactamase resulting in a restoration of the antimicrobial activity of Amoxicillin against lactamase-secreting-resistant bacteria.

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