NISMOL-TH8 Tablets contains Aceclofenac and Thiocolchicoside. Aceclofenac has an excellent efficacy as it easily penetrates into inflammatory tissues of joints and the like, and thus exhibits an excellent action of inhibiting prostaglandin production, as compared to other anti-inflammatory analgesic drugs. Thiocolchicoside is a muscle relaxant, anti-inflammatory and analgesic, used for the treatment of orthopedic, traumatic and rheumatologic disorders.
Aceclofenac is a NSAID, analgesic, anti-arthritic. Thiocolchicoside is a muscle relaxant which has been claimed to possess GABA-mimetic and glycinergic action.
NISMOL-TH8 Tablets can be used in the treatment of the following conditions:
- Post-operative pain, neck and shoulder pain, sciatica.
- Painful spasm associated with lower back pain, degenerative vertebral disorders, dorsal pain, torticollis, traumatological and neurological disorders.
- Pain associated with ankylosing spondylitis, osteoarthritis and rheumatoid arthritis.
One NISMOL-TH8 Tablet twice daily or as directed by Physician.
Aceclofenac inhibits cyclooxygenase (COX) activity and to suppress the PGE2 production by inflammatory cells, by inhibiting IL-Beta & TNF in the inflammatory cells (Intracellular Action). It act by decreasing the prostaglandin in the body.
The mode of action of Thiocolchicoside includes modulation of chemokine and prostanoid production and inhibition of neutrophil and endothelial cell adhesion molecules by which it interferes with the initiation and amplification of the joint inflammation.