Ceftriaxone is a broad spectrum cephalosporin antibiotic. Sulbactam is a semi-synthetic beta-lactamase inhibitor.

One GLICEF-S Injection every 6 hours or as directed by Physician.

GLICEF-S Injection can be used in the treatment of following conditions:

• Sepsis, Meningitis
• Abdominal infections
• Infections of the bones, joints, soft tissue, skin and wounds
• Infections in patients with impaired defense mechanisms
• Renal and urinary tract infections
• Respiratory tract infections, pneumonia, and ear, nose and throat infections
• Genital infections, including gonorrhoea

Ceftriaxone inhibits bacterial cell wall synthesis by means of binding to the penicillin-binding proteins (PBPs). Inhibition of PBPs would in turn inhibit the transpeptidation step in peptidoglycan synthesis which is required for bacterial cell walls. Sulbactam is an irreversible inhibitor of β-lactamase; it binds to the enzyme and does not allow it to degrade the antibiotic.