NISPAM
Overview:
Nispam (Pralidoxime Chloride Injection) is an antidote used in the treatment of organophosphate poisoning caused by pesticides, nerve agents, or chemical exposure. It works by reactivating acetylcholinesterase, an enzyme crucial for nerve function, thereby reversing neuromuscular paralysis and restoring normal muscle activity. Nispam is a critical emergency medication commonly used in toxicology and critical care settings.
- Class
- Dosage
- Indications
- Mechanism of Action
Natural Laxative
- Adults: 1–2 g intravenously (IV) over 15–30 minutes, repeated if necessary based on clinical response.
- Pediatrics: 20–50 mg/kg IV infusion over 15–30 minutes.
- In severe poisoning cases, continuous infusion may be required.
- Always administer under medical supervision in a hospital setting.
Nispam can be used in the treatment of the following conditions:
- Organophosphate poisoning from pesticides, insecticides, or chemical warfare agents
- Reversal of neuromuscular blockade caused by organophosphates
- Supportive therapy in cholinergic crisis
Pralidoxime works by binding to phosphorylated acetylcholinesterase, breaking the bond formed by organophosphates, and restoring enzyme activity. This leads to the breakdown of excess acetylcholine, helping to reverse muscle weakness, respiratory depression, and cholinergic symptoms caused by poisoning. It is often used alongside atropine for optimal antidotal therapy