OCTRONIS
Overview:
Octronis (Octreotide 100 mcg Injection) is a potent somatostatin analog used to control excessive hormone secretion, particularly in conditions like acromegaly, neuroendocrine tumors, and severe diarrhea associated with carcinoid syndrome. It effectively inhibits growth hormone (GH), insulin, glucagon, and gastrointestinal secretions, making it a critical treatment for hormone-related disorders
- Class
- Dosage
- Indications
- Mechanism of Action
Somatostatin Analog
Acromegaly: 50-100 mcg subcutaneously (SC) every 8-12 hours, adjustable based on response
Neuroendocrine tumors: 100-500 mcg SC every 8-12 hours
Gastrointestinal bleeding (esophageal varices): 25-50 mcg/hour via continuous IV infusion
Postoperative pancreatic fistulas: 100 mcg SC every 8 hours
- Acromegaly (excess growth hormone production)
- Neuroendocrine tumors (NETs), including carcinoid tumors and VIPomas
- Severe diarrhea and flushing associated with carcinoid syndrome
- Gastrointestinal bleeding (esophageal varices in liver cirrhosis)
- Postoperative pancreatic surgery complication
Octreotide mimics natural somatostatin, inhibiting the release of growth hormone, insulin, glucagon, and vasoactive peptides. This results in reduced hormone overproduction, controlling symptoms such as diarrhea, flushing, and tumor growth. It also reduces blood flow to the gastrointestinal tract, aiding in variceal bleeding management.
