Methylcobalamin is a cobalamin an active form of Vitamin B12. Pregabalin is a potent gabapentinoid and structural analogue of the neurotransmitter GABA. It is a ion channel modulator that has rapid analgesic, anticonvulsant, and anxiolytic effects.
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ARENA
(Pregabalin 75 mg + Mecobalamin 750 mcg Capsules)
Overview:
ARENA Capsules contains Methylcobalamin and Pregabalin. Methylcobalamin is the neurologically active form of Vitamin B12, used by the enzyme methionine synthase to turn homocysteine (HCY) into methionine. Methionine is further converted to the important methyl donor, S-adenosylmethionine (SAMe). Pregabalin is a structural analogue of the neurotransmitter gamma-aminobutyric acid (GABA).
- Class
- Dosage
- Indications
- Mechanism of action
ARENA Capsules can be used in the treatment of the following conditions:
- Peripheral Neuropathy
- Diabetic Neuropathy (includes burning sensation, numbness, loss of sensation & muscle cramps)\
- Drug Induced Neuropathy
- Adjuct to partial seizures
- Bell’s Palsy
- Fibromyalgia
- Sciatica and other conditions.
Mecobalamin or Vitamin B12 is normally involved in several metabolism such as DNA synthesis and regulation, fatty acid synthesis, and energy production. It is a coenzyme of methionine synthase, which is required for the formation of methionine from homocysteine in the methylation cycle which involves methylation of DNA or proteins. Compared with other analogue. Mecobalamin is the most effective one in being uptaken by subcellular organelles of neurons. Pregabalin may reduce excitatory neurotransmitter release by binding to the α2-δ protein subunit of voltage-gated calcium channels.
