TRANY
Overview:
Tramadol is a centrally acting synthetic opioid analgesic with a unique dual mechanism of action that makes it highly effective for moderate to severe pain management. Unlike traditional opioids, tramadol exhibits a multimodal approach by combining opioid receptor agonism with monoaminergic modulation, making it particularly useful in postoperative, neuropathic, and chronic pain conditions.
This formulation, Tramadol 2ml Injection, is a parenteral preparation designed for rapid onset of action, making it an essential option in both acute pain relief and perioperative care.
- Class
- Indications
- Dosage
- Mechanism of action
Opioid Analgesic (Centrally Acting)
Trany Tablets can be used in the treatment of the following conditions:
Moderate to severe pain management (postoperative pain, trauma, chronic pain).
Neuropathic pain.
Pain in conditions where NSAIDs are not recommended (e.g., GI ulcers, kidney disease).
Adjunct in anesthesia or post-surgical recovery.
Route of Administration: IV, IM, or slow infusion
Recommended Dosage:
Acute pain relief: 50–100 mg IV/IM every 4–6 hours as needed
Maximum daily dose: 400 mg/day
Tramadol works through a dual mechanism:
Opioid receptor agonism: Tramadol binds weakly to mu-opioid receptors (μ-receptors), providing analgesic effects.
Monoamine reuptake inhibition: It inhibits the reuptake of serotonin and norepinephrine, enhancing pain modulation at the spinal level.