Overview of Aceclofenac + Rabeprazole Capsules:
NISMOL PLUS Capsule contains Aceclofenac 200mg and Rabeprazole 20mg. Aceclofenac has an excellent efficacy against chronic joint diseases, including rheumatoid arthritis, osteoarthrosis and ankylosing spondylitis, as well as dentalgia, post-operation pain or post-delivery pain. This drug shows an excellent therapeutic effect in that it easily penetrates into inflammatory tissues occurring in a joint and the like, and thus exhibits an excellent action of inhibiting prostaglandin production, as compared to other anti-inflammatory analgesic drugs. Rabeprazole act as an anti-ulcerative drug.
NISMOL PLUS Capsule can be used in the managment of pain and inflammation in the following conditions:
- Rheumatoid arthritis
- Osteoarthritis
- Ankylosing spondylitis
- Acute gout
- Post operative pain
- Dental pain
- Painful musculoskeletal condition
- Low back pain
One NISMOL PLUS Capsule daily.
Aceclofenac inhibits cyclooxygenase (COX) activity and to suppress the PGE2 production by inflammatory cells, by inhibiting IL-Beta & TNF in the inflammatory cells (Intracellular Action). Rabeprazole suppress gastric acid secretion by inhibiting gastric H+K+ATPase at the secretory surface, of the gastric parietal cells. Rabeprazole act by blocking the H+P+ ATPase enzyme of the gastric parietal cells, thus inhibit last stage of gastric acid secretion.
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